VERR_SUPLIB_OWNER_NOT_ROOT on VirtualBox

A couple of days ago I had a problem with VirtualBox, I couldn’t start one of my VMs because it was displaying an error message saying: “VERR_SUPLIB_OWNER_NOT_ROOT”
Searching on the internet I found this bug. and they suggested to run:

This didn’t fix my issue, so I started to dig deeply into the issue and I found a log file on ~/.VirtualBox/Machines/VM/Logs/VBox.log with the following message:

I took a quick look at /usr permissions and I found that for some weird reason, it had uid:gid 500:500

Solution: